The main objective of this work package is to set up an effective management framework to ensure that ShigaPlexIM progresses towards its planned objectives in line with contractual commitments. The specific objectives are to:

• Set-up an efficient management infrastructure including management bodies, independent scientific and ethics advisory committee, data safety and monitoring board, and management procedures and tools

• Ensure observance of the required ethical standards

• Conduct contractual management of the consortium

• Implement day-to-day operational ShigaPlexIM management